Assist. Prof. Dr. Hadi Maleki-Kakelar, Urmia University of Medical Sciences, Iran
Assist. Prof. Dr. Hadi Maleki-Kakelar is an Assistant Professor at the Solid Tumor Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Iran. He holds an M.Sc. in Microbiology from the University of Zanjan (2007) and a Ph.D. in Medical Biotechnology from Tabriz University of Medical Sciences (2014).
Education:
Assistant Professor
Solid Tumor Research Center, Urmia University of Medical Sciences, Urmia, Iran
August 2022
Postdoctoral Researcher
Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
April 2019 – February
Supervisor: Prof. Y. Omidi
Ph.D. in Medical Biotechnology (Sep 2014 – Apr 2019)
Institution: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences (TBZMED), Tabriz, Iran
Thesis: Nano-engineered edible probiotic bacteria to combat Helicobacter pylori
Supervisor: Prof. Y. Omidi
GPA: 20/20
M.Sc. in Microbiology (Sep 2007 – Sep 2010)
Institution: Faculty of Microbiology, Islamic Azad University, Zanjan, Iran
Thesis: Survey of Extracted Secondary Metabolites of Streptomyces spp. with Antibacterial Properties Isolated from Soils of West Azarbayjan and Kordestan Regions
Supervisor: Prof. Y. Omidi
GPA: 19.50/20
Professional Profiles:
ORCID ID
Scopus Profile
Professional Experience:
Classification and Genotyping of Bacteria: Conducting research on bacterial species identification using advanced genotyping techniques, contributing to the understanding of bacterial diversity and its applications in medicine.
DNA Extraction: Performing high-quality DNA extractions from various biological samples, ensuring the integrity and purity of DNA for downstream molecular applications.
Isolation and Molecular Identification of Marine Microorganisms: Isolating unique marine microorganisms with potential pharmaceutical properties and using molecular methods such as 16S rRNA sequencing for species identification.
Cloning and Expression of Recombinant Proteins: Cloning genes of interest and expressing recombinant proteins in bacterial or mammalian systems to study their potential applications in drug development and biotechnology.
PCR, qRT-PCR: Employing PCR and quantitative PCR (qRT-PCR) techniques to analyze gene expression and detect specific genetic markers in bacterial and mammalian samples.
Cell Culture and Bacterial Culture: Managing cell culture techniques, including maintaining mammalian and bacterial cell lines, to support research in drug discovery and pharmaceutical nanotechnology.
Synthesis of Nanoparticles: Synthesizing nanoparticles, including gold nanoparticles, for use in drug delivery systems, cancer therapy, and diagnostic applications.
Working with Animal Models: Designing and conducting experiments using animal models (mice, rats, and rabbits) to study the in vivo effects of pharmaceutical compounds and nanomaterials in therapeutic research.
Research Interests:
His research focuses on cellular and molecular biotechnology, including nano-engineered probiotic bacteria for combating Helicobacter pylori. Dr. Maleki-Kakelar is a dedicated researcher with a strong background in microbiology, nanotechnology, and biomedical sciences.
Top Notable Publications:
Recent advances in the application of engineered exosomes from mesenchymal stem cells for regenerative medicine
European Journal of Pharmacology
2025-02
DOI: 10.1016/j.ejphar.2024.177236
Contributors: Reza Abbasi, Ghazal Alamdari-Mahd, Hadi Maleki-Kakelar, Razieh Momen-Mesgin, Mahdi Ahmadi, Mohaddeseh Sharafkhani, Jafar Rezaie
The role of gut microbiota and probiotics in preventing, treating, and boosting the immune system in colorectal cancer
Life Sciences
2024
DOI: 10.1016/j.lfs.2024.122529
Contributors: Masheghati, F.; Asgharzadeh, M.R.; Jafari, A.; Masoudi, N.; Maleki-Kakelar, H.
Infertility: Focus on the therapeutic potential of extracellular vesicles
Reproductive Biology
2024-09
DOI: 10.1016/j.repbio.2024.100925
Contributors: Ali Parvin, Gisou Erabi, Donna Mohammadpour, Hadi Maleki-Kakelar, Sonia Sadeghpour, Mohammad Reza Pashaei, Mortaza Taheri-Anganeh, Hojat Ghasemnejad-Berenji
Association of endothelial nitric oxide synthase gene polymorphisms with susceptibility to prostate cancer: A comprehensive systematic review and meta-analysis
Urology Journal
2020
DOI: 10.22037/uj.v0i0.5445
Contributors: Abedinzadeh, M.; Dastgheib, S.A.; Maleki, H.; Heiranizadeh, N.; Zare, M.; Jafari-Nedooshan, J.; Kargar, S.; Neamatzadeh, H.
Towards a new avenue for producing therapeutic proteins: Microalgae as a tempting green biofactory
Biotechnology Advances
2019-12
DOI: 10.1016/j.biotechadv.2019.107499
Contributors: Dehghani J; Adibkia K; Movafeghi A; Maleki-Kakelar H; Saeedi N; Omidi Y
Lactobacillus plantarum induces apoptosis in gastric cancer cells via modulation of signaling pathways in Helicobacter pylori
BioImpacts
2019-06
DOI: 10.34172/bi.2020.09
Contributors: Maleki-Kakelar H; Dehghani J; Barzegari A; Barar J; Shirmohamadi M; Sadeghi J; Omidi Y
Novel dental nanocomposites: Fabrication and investigation of their physicochemical, mechanical, and biological properties
Bulletin of Materials Science
2018
DOI: 10.1007/s12034-018-1589-z
Contributors: Jaymand, M.; Lotfi, M.; Barar, J.; Eskandani, M.; Maleki, H.
Propyl gallate (PG) and tert-butylhydroquinone (TBHQ) may alter the potential anti-cancer behavior of probiotics
Food Bioscience
2018
DOI: 10.1016/j.fbio.2018.05.005
Contributors: Salmanzadeh, R.; Eskandani, M.; Mokhtarzadeh, A.; Vandghanooni, S.; Ilghami, R.; Maleki, H.; Saeeidi, N.; Omidi, Y
Isolation and molecular identification of Lactobacillus with probiotic potential from abomasums driven rennet
Food Chemistry
2018-08
DOI: 10.1016/j.foodchem.2018.08.081
Contributors: Maleki Kakelar H; Barzegari A; Hanifian S; Barar J; Omidi Y
Pathogenicity of Helicobacter pylori in cancer development and impacts of vaccination
Gastric Cancer
2018-08
DOI: 10.1007/s10120-018-0867-1
Contributors: Maleki Kakelar H; Barzegari A; Dehghani J; Hanifian S; Saeedi N; Barar J; Omidi Y
Conclusion:
In conclusion, Dr. Hadi Maleki-Kakelar’s diverse body of work, encompassing significant research in regenerative medicine, cancer immunology, and microbiology, positions him as an exceptional candidate for the Best Researcher Award. His continued pursuit of innovation, dedication to advancing scientific understanding, and ability to generate impactful, globally relevant research make him a leader in his field. Dr. Maleki-Kakelar is undoubtedly deserving of this prestigious recognition, and his work continues to inspire future generations of scientists and researchers.