Mrs. Jingyi Jin has made significant contributions to the field of pharmacokinetics through her extensive research endeavors. Since May 2018, she has been investigating the pharmacokinetics of Da-Huang-Xiao-Shi Decoction in mice, focusing on understanding the absorption, distribution, metabolism, and excretion of this traditional Chinese medicinal formulation. Her work aims to elucidate the pharmacological basis of its therapeutic effects and optimize its clinical use. From May 2017 to April 2018, Mrs. Jin studied the transport mechanisms of venlafaxine and its main metabolite, O-desmethylvenlafaxine, in hCMEC/D3 cells. This research was pivotal in understanding how these compounds cross the blood-brain barrier, providing insights into their efficacy and safety as antidepressants. Prior to this, she examined the involvement of P-glycoprotein and multidrug and toxin extrusion protein 1 in the hepatic and renal efflux of berberine in mice from September 2015 to April 2017. This study highlighted the roles of these transport proteins in drug-drug interactions and their impact on berberine’s bioavailability and therapeutic effectiveness. Mrs. Jin’s early research, conducted from December 2014 to August 2015, focused on the absorption interaction between berberine and metformin in vitro. This study explored the synergistic effects of these two compounds, commonly used in the treatment of type 2 diabetes, and provided a foundation for optimizing combination therapies. Through these diverse research projects, Mrs. Jin has demonstrated a robust ability to conduct detailed pharmacokinetic studies, contributing valuable knowledge to the field and enhancing the scientific understanding of traditional Chinese medicines and modern pharmaceuticals.

Mrs. Jingyi Jin possesses a comprehensive set of experimental skills, honed through years of rigorous academic training and hands-on research experience. She is proficient in the routine operation of mice and rats, which includes handling, dosing, and sample collection. Her expertise in animal studies is complemented by her proficiency in cell culture techniques, where she excels in the cultivation and maintenance of various cell lines. Mrs. Jin is also skilled in transfection technology, enabling her to introduce foreign DNA into cells to study gene function and expression. In addition to these foundational skills, Mrs. Jin has mastered several advanced analytical techniques. She is experienced in conducting transport assays, which are critical for understanding the movement of substances across cell membranes. Her technical repertoire includes the use of sophisticated instruments such as the Thermo Scientific TSQ and LCQ mass spectrometers, and she is familiar with Ultra-Performance Liquid Chromatography (UPLC) and the 5500 QTRAP system. These skills are crucial for the establishment and validation of analytical methods used in pharmacokinetic studies. Mrs. Jin’s ability to integrate these diverse experimental techniques demonstrates her versatility and depth of knowledge in pharmacokinetics and drug metabolism. Her proficiency with both in vivo and in vitro models positions her as a valuable asset in the field of pharmacokinetics research, contributing to the advancement of our understanding of drug interactions and mechanisms.