Santina Bruzzone,Università di Genova,Italy
Santina Bruzzone is a Full Professor of Biochemistry at the University of Genova, Italy. She was born on February 21, 1972, in Genova, Italy. Her research focuses on the role of NAD+ and NAD+-converting enzymes in inflammation and cancer.
Publication Profile
Scopus
Education
Santina Bruzzone completed her high school education at Liceo Scientifico L. Lanfranconi in Genova, Italy, from 1986 to 1991. She then earned her degree in Biology from the University of Genova, graduating cum laude with a score of 110/110 in 1996. She received her Ph.D. in Biotechnology applied to Pharmacology and Cellular and Molecular Biotechnology applied to Biomedicine from the University of Milano from 1996 to 2000.
Experince
Santina Bruzzone worked as a postdoctoral researcher at the Department of Experimental Medicine (DIMES)–Section of Biochemistry, University of Genova, from January to March 2001. She then worked as a postdoctoral researcher at the Department of Pharmacology, University of Minnesota, from April to December 2001. She returned to the University of Genova as a postdoctoral researcher from 2002 to 2005 and later became an Assistant Professor of Biochemistry from 2005 to 2016. She was promoted to Associate Professor of Biochemistry from 2016 to 2021 and became a Full Professor of Biochemistry in 2021.
Award and Honors
Santina Bruzzone received several awards and honors, including the Fellowship for training abroad from Consorzio Interuniversitario Biotecnologie (CIB) in 2001, the Fellowship for training abroad from the University of Genova in 2001, and the Faculty Research Visit Grant from DAAD (German Academic Exchange Service) in 2013.
Research Focus
Santina Bruzzone’s research focuses on the role of NAD+ and NAD+-converting enzymes in inflammation and cancer. Her work explores the molecular mechanisms underlying the regulation of NAD+ metabolism and its impact on cellular processes such as energy metabolism, cell signaling, and cell death.
Publications
1. 🌟 CD38 and ADP-ribosyl cyclase catalyze the synthesis of a dimeric ADP-ribose that potentiates the Calcium-mobilizing activity of Cyclic ADP-ribose. (1997)
2. 🌟 Ectocellular CD38-catalyzed synthesis and intracellular Ca2+-mobilizing activity of Cyclic ADP-ribose. (1998)
3. 🌟 Expression of CD38 increases intracellular calcium concentration and reduces doubling time in HeLa and 3T3 cells. (1998)
4. 🌟 The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger Cyclic ADPribose across membranes. (1998)
5. 🌟 Dimeric and tetrameric forms of catalytically active transmembrane CD38 in transfected HeLa cells. (1998)
6. 🌟 Ligand-induced internalization of CD38 results in intracellular Ca2+ mobilization. (1999)
7. 🌟 Topology of CD38. (2000)
8. 🌟 Extracellular cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors. (2000)
9. 🌟 G(s) protein dysfunction in allergen-challenged human isolated passively sensitized bronchi. (2000)
10. 🌟 Connexin 43 hemichannels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells. (2001)
11. 🌟 Extracellular Cyclic ADP-ribose potentiates Ach-induced contraction in bovine tracheal smooth muscle. (2001)
12. 🌟 Human CD38 and its ligand CD31 define a unique lamina propria T lymphocyte signaling pathway. (2001)
13. 🌟 Paracrinally stimulated expansion of early human hemopoietic progenitors by stroma-generated cyclic ADP-ribose. (2001)
14. 🌟 Paracrine roles of NAD+ and Cyclic ADP-ribose in increasing intracellular calcium and enhancing cell proliferation of 3T3 fibroblasts. (2001)
15. 🌟 Autocrine abscisic acid mediates the UV-B-induced inflammatory response in human granulocytes and keratinocytes. (2012)
16. 🌟 ABA says NO to UV-B: a universal