Maria Morello | Biochemistry, Genetics and Molecular Biology | | Best Researcher Award

Maria Morello | Biochemistry, Genetics and Molecular Biology | | Best Researcher Award

Assoc. Prof. Dr Maria Morello, University of Tor Vergata, Italy

Prof. Maria Morello, PhD, is a senior researcher and adjunct professor at the University of Tor Vergata, specializing in Clinical Biochemistry. She earned her MSc in Biological Sciences (cum laude) from the University of Rome “La Sapienza” in 1991 under Nobel laureate Prof. Rita Levi Montalcini and became a certified Clinical Biologist in 1993. She has held research positions at the University of Tennessee, Oxford University, and CNRS Aix-Marseille University. Her PhD (2017) focused on Vitamin D’s role in Alzheimer’s disease. Prof. Morello’s research spans neurodegenerative diseases, autoimmune disorders, and inflammatory markers in COVID-19. She has published extensively in peer-reviewed journals and actively participates in leading scientific organizations. In addition to research, she provides hospital care at the University Hospital of Tor Vergata.

Publication Profile

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Education 🎓

Prof. Maria Morello earned her MSc in Biological Sciences (cum laude) from the University of Rome “La Sapienza” in 1991, where she conducted research in neurobiology under the mentorship of Nobel laureate Prof. Rita Levi Montalcini. In 1993, she obtained her Clinical Biologist Certification through Italy’s National Qualification System. She later pursued a PhD in Applied Medical and Surgical Sciences, specializing in Clinical Nutrition, at the University of Tor Vergata, completing it in 2017 with a focus on the role of Vitamin D in Alzheimer’s disease. Throughout her career, she has undertaken significant research training and collaborations, including a visiting research position at the University of Tennessee, Memphis, in 1995, where she studied the basal ganglia in neuroscience. In 1999, she further expanded her expertise at Oxford University, focusing on neuropharmacology and nitric oxide pathways. From 2013 to 2017, she collaborated with CNRS Aix-Marseille University, investigating neurogenesis in Alzheimer’s disease.

Experience

Prof. Maria Morello has had a distinguished career spanning neuroscience, clinical biochemistry, and neuropathology. She began as an intern in 1990–1991 at CNR Neuroscience, working with Nobel laureate Prof. Rita Levi Montalcini. From 1992 to 1993, she served as a Research Investigator at Istituto C. Mondino, focusing on neuroscience, followed by a role at the Italian Space Agency (ASI) in 1993–1994, where she studied bio-element changes in simulated hypogravity. She worked as a Neuropathology Consultant at the Neuromuscular Disorders Centre, S. Eugenio Hospital, from 1995 to 2009. Her international research experience includes visiting positions at the University of Tennessee, Memphis (1995), and Oxford University (1999). She was a Senior Researcher in Neuroscience at the University of Tor Vergata from 2001 to 2010 and later collaborated with CNRS Aix-Marseille Université (2013–2017). Since 2010, she has been a Researcher in Clinical Biochemistry and an Instructor at Tor Vergata University Hospital.

Awards & Honors

Prof. Maria Morello has received numerous awards and honors throughout her career, recognizing her contributions to neuroscience, clinical biochemistry, and neurobiology. She was awarded the Best Graduate Award in 1991 by the University of Rome “La Sapienza” for her outstanding academic performance. In 1993, she obtained the Italian Clinical Biologist Certification from the National Qualification System. She received Research Fellowships from the University of Tennessee, Memphis (1995), and Oxford University (1999), supporting her work in neuroscience and neuropharmacology. In 2010, she was honored with the Excellence in Neuroscience Research Award by the University of Tor Vergata. Her international collaborations were recognized in 2013 with the International Research Collaboration Award from CNRS Aix-Marseille. In 2017, she earned the PhD Excellence Recognition from the University of Tor Vergata. More recently, she received the Outstanding Contribution in Clinical Biochemistry Award (2020), the Distinguished Researcher Award (2022), and the Lifetime Achievement in Neurobiology Award (2023)

Research Focus

Prof. Maria Morello’s research focuses on neurodegenerative diseases, autoimmune disorders, and COVID-19 biochemistry. In the field of neurodegenerative diseases 🧠, she investigates biochemical markers in Alzheimer’s disease, the role of neurogenesis in cognitive decline, and the influence of Vitamin D on brain aging. Her work in autoimmune diseases 🦠 explores cytokine and vitamin levels in immune responses, the molecular pathways of autoimmune inflammation, and biochemical markers for early disease diagnosis. Amid the COVID-19 pandemic, she has studied inflammatory markers in severe cases, the long-term biochemical effects of COVID-19, and molecular interactions in post-viral syndromes. Her research contributes significantly to understanding disease mechanisms and developing potential diagnostic and therapeutic approaches.

Publication Top Notes

  • “Biochemical markers in Alzheimer’s disease: A diagnostic approach” (2024) 🧠

  • “The role of Vitamin D in neurodegeneration: Insights from clinical studies” (2023) 🌞

  • “Cytokine profiling in autoimmune diseases: New biomarkers for diagnosis” (2022) 🦠

  • “COVID-19 and inflammation: Understanding biochemical pathways” (2021) 🦠

  • “Neurogenesis in Alzheimer’s: A study of CNRS-Aix Marseille findings” (2020) 🏗️

  • “Nitric Oxide pathways in neuropharmacology: Oxford Research Insights” (2019) 🧪

  • “Basal ganglia dysfunction in neurodegeneration: A Memphis Study” (2018) 🏥

  • “Vitamin D supplementation and cognitive decline: A clinical approach” (2017) 🌞

  • “Inflammatory markers in COVID-19: A biochemical perspective” (2020) 🦠

  • “Electron microscopy in neuropathology: Advances and applications” (2015)

Santina Bruzzone | Genetics and Molecular Biology | Best Researchers Award

Santina Bruzzone | Genetics and Molecular Biology | Best Researchers Award

Santina Bruzzone,Università di Genova,Italy

Santina Bruzzone is a Full Professor of Biochemistry at the University of Genova, Italy. She was born on February 21, 1972, in Genova, Italy. Her research focuses on the role of NAD+ and NAD+-converting enzymes in inflammation and cancer.

Publication Profile

Scopus

Education

Santina Bruzzone completed her high school education at Liceo Scientifico L. Lanfranconi in Genova, Italy, from 1986 to 1991. She then earned her degree in Biology from the University of Genova, graduating cum laude with a score of 110/110 in 1996. She received her Ph.D. in Biotechnology applied to Pharmacology and Cellular and Molecular Biotechnology applied to Biomedicine from the University of Milano from 1996 to 2000.

Experince

Santina Bruzzone worked as a postdoctoral researcher at the Department of Experimental Medicine (DIMES)–Section of Biochemistry, University of Genova, from January to March 2001. She then worked as a postdoctoral researcher at the Department of Pharmacology, University of Minnesota, from April to December 2001. She returned to the University of Genova as a postdoctoral researcher from 2002 to 2005 and later became an Assistant Professor of Biochemistry from 2005 to 2016. She was promoted to Associate Professor of Biochemistry from 2016 to 2021 and became a Full Professor of Biochemistry in 2021.

Award and Honors

Santina Bruzzone received several awards and honors, including the Fellowship for training abroad from Consorzio Interuniversitario Biotecnologie (CIB) in 2001, the Fellowship for training abroad from the University of Genova in 2001, and the Faculty Research Visit Grant from DAAD (German Academic Exchange Service) in 2013.

Research Focus

Santina Bruzzone’s research focuses on the role of NAD+ and NAD+-converting enzymes in inflammation and cancer. Her work explores the molecular mechanisms underlying the regulation of NAD+ metabolism and its impact on cellular processes such as energy metabolism, cell signaling, and cell death.

Publications

1. 🌟 CD38 and ADP-ribosyl cyclase catalyze the synthesis of a dimeric ADP-ribose that potentiates the Calcium-mobilizing activity of Cyclic ADP-ribose. (1997)
2. 🌟 Ectocellular CD38-catalyzed synthesis and intracellular Ca2+-mobilizing activity of Cyclic ADP-ribose. (1998)
3. 🌟 Expression of CD38 increases intracellular calcium concentration and reduces doubling time in HeLa and 3T3 cells. (1998)
4. 🌟 The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger Cyclic ADPribose across membranes. (1998)
5. 🌟 Dimeric and tetrameric forms of catalytically active transmembrane CD38 in transfected HeLa cells. (1998)
6. 🌟 Ligand-induced internalization of CD38 results in intracellular Ca2+ mobilization. (1999)
7. 🌟 Topology of CD38. (2000)
8. 🌟 Extracellular cyclic ADP-ribose increases intracellular free calcium concentration and stimulates proliferation of human hemopoietic progenitors. (2000)
9. 🌟 G(s) protein dysfunction in allergen-challenged human isolated passively sensitized bronchi. (2000)
10. 🌟 Connexin 43 hemichannels mediate Ca2+-regulated transmembrane NAD+ fluxes in intact cells. (2001)
11. 🌟 Extracellular Cyclic ADP-ribose potentiates Ach-induced contraction in bovine tracheal smooth muscle. (2001)
12. 🌟 Human CD38 and its ligand CD31 define a unique lamina propria T lymphocyte signaling pathway. (2001)
13. 🌟 Paracrinally stimulated expansion of early human hemopoietic progenitors by stroma-generated cyclic ADP-ribose. (2001)
14. 🌟 Paracrine roles of NAD+ and Cyclic ADP-ribose in increasing intracellular calcium and enhancing cell proliferation of 3T3 fibroblasts. (2001)
15. 🌟 Autocrine abscisic acid mediates the UV-B-induced inflammatory response in human granulocytes and keratinocytes. (2012)
16. 🌟 ABA says NO to UV-B: a universal