Lan Wang | Biochemistry | Best Researcher Award

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Dr. Lan Wang | Biochemistry | Best Researcher Award

Principal Investigator at Shanghai Institute of Nutrition and Health, China

Dr. Lan Wang is a distinguished researcher specializing in the pathogenesis of hematological malignancies and stem cell studies. She earned her Bachelorā€™s degree from Fudan University and completed her Ph.D. at the Institute of Health Sciences, Shanghai Institute of Life Science, Chinese Academy of Science. Dr. Wang held notable academic positions at Memorial Sloan-Kettering Cancer Center and the University of Miami before becoming a Principal Investigator at the Shanghai Institute of Nutrition and Health, SINH, CAS. Her research is dedicated to identifying disrupted genes in hematological disorders and developing therapeutic strategies. Dr. Wang has received numerous honors, including the Leukemia Lymphoma Society Fellowship, the Empire State Stem Cell Scholars Fellow to Faculty award, and the China National Funds for Excellent Young Scientists. She holds several patents related to cancer therapies and serves as an editor for Frontiers in Biosciences. Her work significantly contributes to advancing the understanding and treatment of blood-related cancers.

Professional Profiles:

šŸ“š Education:

Dr. Lan Wang received a Bachelorā€™s degree from Fudan University between 1998 and 2002. Subsequently, from 2002 to 2007, Dr. Wang pursued a Ph.D. at the Institute of Health Sciences, Shanghai Institute of Life Science, Chinese Academy of Science.

Professional Experience:

Dr. Lan Wang held several major academic appointments throughout her career. From 2008 to 2010, she served as a Research Fellow at Memorial Sloan-Kettering Cancer Center. Following this, she was a Research Associate at the same institution from 2010 to 2012. She then became an Assistant Professor in the Department of Biochemistry and Molecular Biology at the Miller School of Medicine, University of Miami, from 2013 to 2015. Since 2015, Dr. Wang has been a Principal Investigator at the Shanghai Institute of Nutrition and Health, SINH, CAS.

Research Interest :

Dr. Lan Wang’s research focuses on understanding the pathogenesis of hematological malignancies and stem cell studies. Specifically, Dr. Wang is interested in identifying the genes disrupted in these disorders and developing new therapeutic strategies for patients with these diseases. Blood cells are generated by hematopoietic stem cells, which are proposed to be the cell of origin in leukemia. Dr. Wang’s research aims to understand how the behavior of these stem cells goes awry when they become transformed. Cancer stem cells exhibit a loss of normal growth control mechanisms, leading to abnormal cell division, survival, and expansion. The development of hematological malignancies is commonly associated with aberrant transcriptional regulation, where genes are inappropriately turned on or off. In most cases, correcting these abnormalities would block the development or progression of hematological malignancies in patients.

Patents :

Dr. Lan Wang holds several patents in the field of therapeutic strategies for cancer treatment. The first patent, co-authored with Nimer SD, is titled “The Novel Therapeutic Strategy for Acute Myeloid Leukemia” with the application number SK2011-037-03, filed in 2011. The second patent, co-authored with Chen Z, Chen SJ, Zhou GB, Liu SC, and Liu P, involves the application of AS4S4/Indigo/Tanshinone IIA for cancer therapy, under the application number 200910051409.5. Another patent, co-authored with Chen SJ, Chen Z, Zhao WL, and Sun HD, covers the application of Eriocalyxin B in pharmacy, with the application number 200510110089.8. The fourth patent, involving Chen Z, Chen SJ, Zhao WL, and Liu YH, is for a medicine combination for the therapy of B-cell lymphoma, with the application number 2005101121147.0.

Awards and Honors:

Dr. Lan Wang has received numerous honors, certificates, and memberships in academic societies throughout her career. In 2005, she was recognized as an Excellent Student by the Chinese Academy of Sciences and received the “Chen Zhu and Chen Saijuan” Award for Outstanding Graduate Student from the Shanghai Institute of Hematology for 2005-2006. In 2009, she was awarded the Leukemia Lymphoma Society Fellowship. She received the American Society of Hematology meeting travel award in 2010 and was appointed as an Associate Faculty Member for the Faculty of 1000 Post-publication peer review in the same year. In 2011, she was honored with the Empire State Stem Cell Scholars Fellow to Faculty award. Dr. Wang became a member of the Sylvester Comprehensive Cancer Center in 2013. From 2014 to 2015, she received several awards, including the Gabrielle’s Angel Foundation for Cancer Research award, The Woman’s Cancer Association of the University of Miami award, and the Leukemia Research Foundation New Investigator award. In 2015, she was granted the Stanley J. Glaser Foundation Award and was a recipient of the Recruitment Program of Global Experts (Young Program). Additionally, she became an Editor of Frontiers in Biosciences. In 2016, Dr. Wang received the China National Funds for Excellent Young Scientists and the Excellent Overseas Returnees Award from the Ministry of Human Resources and Social Security.

šŸ“šPublications :

Quantile regression for analyzing heterogeneity in ultra-high dimension

Authors: L. Wang, Y. Wu, R. Li

Journal: Journal of the American Statistical Association

Volume: 107 (497)

Pages: 214-222

Citations: 329

Year: 2012

Quantile-adaptive model-free variable screening for high-dimensional heterogeneous data

Authors: X. He, L. Wang, H.G. Hong

Citations: 289

Year: 2013

Locally weighted censored quantile regression

Authors: H.J. Wang, L. Wang

Journal: Journal of the American Statistical Association

Volume: 104 (487)

Pages: 1117-1128

Citations: 262

Year: 2009

Penalized generalized estimating equations for high-dimensional longitudinal data analysis

Authors: L. Wang, J. Zhou, A. Qu

Journal: Biometrics

Volume: 68 (2)

Pages: 353-360

Citations: 195

Year: 2012

Calibrating non-convex penalized regression in ultra-high dimension

Authors: L. Wang, Y. Kim, R. Li

Journal: Annals of Statistics

Volume: 41 (5)

Pages: 2505

Citations: 192

Year: 2013

Partially linear additive quantile regression in ultra-high dimension

Authors: B. Sherwood, L. Wang

Citations: 140

Year: 2016

A high-dimensional nonparametric multivariate test for mean vector

Authors: L. Wang, B. Peng, R. Li

Journal: Journal of the American Statistical Association

Volume: 110 (512)

Pages: 1658-1669

Citations: 140

Year: 2015

GEE analysis of clustered binary data with diverging number of covariates

Authors: L. Wang

Citations: 121

Year: 2011

An iterative coordinate descent algorithm for high-dimensional nonconvex penalized quantile regression

Authors: B. Peng, L. Wang

Journal: Journal of Computational and Graphical Statistics

Volume: 24 (3)

Pages: 676-694

Citations: 96

Year: 2015

Weighted Wilcoxon-type smoothly clipped absolute deviation method

Authors: L. Wang, R. Li

Journal: Biometrics

Volume: 65 (2)

Pages: 564-571

Citations: 80

Year: 2009