sivakumar singaravelu | Health Professions | Best Researcher Award

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Dr. sivakumar singaravelu | Health Professions | Best Researcher Award

posydoctoral research fellow at university of johannesburg, South Africa

Dr. Sivakumar Singaravelu is a distinguished scientist specializing in biotechnology and biomaterials, with a focus on medical devices for wound healing and bone and tissue regeneration. He earned his Ph.D. in Biotechnology-Biomaterials from the University of Madras, conducting research at the CSIR-Central Leather Research Institute. He has extensive professional experience, including roles as a Postdoctoral Fellow and Senior Scientist, working on projects involving collagen-based biomaterials, 3D bioprinting, and photobiomodulation therapy for diabetic wounds. Dr. Singaravelu’s technical expertise spans the design and development of keratin and collagen-based biomaterials, photomedicine-based therapy, cell-based studies, molecular biology techniques, bio-organic chemistry, microbiology, and in-vivo studies. His work has been recognized with several prestigious fellowships, including the DST-SERB National Postdoctoral Fellowship, the CSIR-SRA Senior Research Associate Fellowship, and the UGC-RGNF Junior and Senior Research Fellowship.

Professional Profiles:

šŸ“š Education:

Dr. Sivakumar Singaravelu holds a Ph.D. in Biotechnology-Biomaterials from the University of Madras, Chennai, India, where he conducted research from 2013 to 2017. His doctoral work was based at the Biological Material Laboratory, CSIR-Central Leather Research Institute in Chennai, and focused on the “Development of Keratin Based Biomaterials for Biomedical Application.” Prior to his Ph.D., Dr. Singaravelu completed his M.Tech in Biotechnology at Sathyabama University, Chennai, India, from 2008 to 2010. He earned his B.Tech in Industrial Biotechnology from the Government College of Technology, Coimbatore, India, between 2003 and 2007.

Professional Experience:

Dr. Sivakumar Singaravelu has an extensive background in biotechnology with a focus on biomaterials, demonstrated through his professional experience. Since July 2023, he has been working as a Postdoctoral Fellow on a project titled “Combined Effect of Biologically Active Dual-Layered Biomaterial and Photobiomodulation for Diabetic Wounds.” From November 2019 to June 2023, Dr. Singaravelu served as a Senior Scientist at SynerHeal Pharmaceuticals Pvt. Ltd in Chennai, India, where he worked on the “Preparation and Development of Collagen-based Biomaterials for Bone and Tissue Regeneration.” Prior to this role, he was a Postdoctoral Fellow at POSTECH in Pohang, Republic of Korea, from March 2019 to September 2019. His project there focused on the “Preparation of Keratin Enriched Human-like Skin by Using a 3D Bioprinter.” Additionally, Dr. Singaravelu was a National Postdoctoral Fellow from June 2017 to February 2019. His project, funded by the DST-SERB, Government of India, involved the development of a “3D Dual Layered Nanofibrous Scaffold Impregnated with Signaling Factors for Bone and Tissue Regeneration.

Teaching Experience:

Dr. Sivakumar Singaravelu possesses extensive technical expertise in the design and development of medical devices and biomaterials, particularly for wound healing and bone and tissue regeneration. His broad area of specialization encompasses the development of keratin and collagen-based biomaterials for wound dressings and tissue regeneration, employing natural and synthetic polymers through methods such as deep freezing and electrospinning. In the field of photomedicine, Dr. Singaravelu has expertise in photobiomodulation therapy, specifically for treating normal and diabetic wounded cells. His cell-based studies include fluorescent and luminescent-based in vitro assays, cell culturing for various cell lines (WS1, MCF-7, A549, HaCaT, and stem cells), as well as cellular uptake and toxicity assays. His molecular biology techniques are comprehensive, including DNA isolation, electrophoresis, RNA extraction, cDNA preparation, PCR, RT-PCR, protein extraction and estimation (SDS-PAGE), Coomassie staining, MTT assay for cell proliferation/cytotoxicity, flow cytometry, and ELISA. In bio-organic chemistry and characterization, Dr. Singaravelu is proficient in biological assays of biomolecules using analytical techniques such as colorimetric and UV spectrophotometry, chromatography techniques, FTIR, DSC, TGA, XRD, FE-SEM, and tensile strength measurement using a texture analyzer. His microbiology skills cover biochemical characterizations, staining and subculturing techniques, antibacterial and antifungal activity screening methods, and the use of confocal and fluorescent microscopy for DAPI and Calcein AM staining. Additionally, Dr. Singaravelu has experience in in-vivo studies, specifically utilizing open excision wound models in male albino Wistar rats, and evaluating total protein and collagen deposition using H&E and Masson’s trichrome staining techniques.

Awards and Honors:

Dr. Sivakumar Singaravelu has received several prestigious awards and honors throughout his academic and professional career. From 2017 to 2019, he was awarded the DST-SERB National Postdoctoral Fellowship. During the same period, he also received the CSIR-SRA Senior Research Associate Fellowship. Additionally, from 2013 to 2017, he was honored with the UGC-RGNF Junior and Senior Research Fellowship.

šŸ“šPublications :

Fabrication and characterization of a collagen coated electrospun poly (3-hydroxybutyric acid)ā€“gelatin nanofibrous scaffold as a soft bio-mimetic material for skin tissue

Authors: G Ramanathan, S Singaravelu, MD Raja, N Nagiah, P Padmapriya, …

Citations: 76

Year: 2016

Design and characterization of 3D hybrid collagen matrixes as a dermal substitute in skin tissue engineering

Authors: G Ramanathan, S Singaravelu, T Muthukumar, S Thyagarajan, …

Citations: 74

Year: 2017

Green synthesis of folic acid-conjugated gold nanoparticles with pectin as reducing/stabilizing agent for cancer theranostics

Authors: RM Devendiran, S Kumar Chinnaiyan, NK Yadav, GK Moorthy, …

Citations: 68

Year: 2016

Biomimetic interconnected porous keratinā€“fibrinā€“gelatin 3D sponge for tissue engineering application

Authors: S Singaravelu, G Ramanathan, MD Raja, N Nagiah, P Padmapriya, …

Citations: 45

Year: 2016

Preparation and characterization of keratin-based biosheet from bovine horn waste as wound dressing material

Authors: S Singaravelu, G Ramanathan, MD Raja, S Barge, UT Sivagnanam

Citations: 42

Year: 2015

Extraction and characterization of collagen from the skin of Arothron stellatus fishā€”A novel source of collagen for tissue engineering

Authors: G Ramanathan, S Singaravelu, MD Raja, SS Sobhana, UT Sivagnanam

Citations: 37

Year: 2014

Durable keratin-based bilayered electrospun mats for wound closure

Authors: S Singaravelu, G Ramanathan, T Muthukumar, MD Raja, N Nagiah, …

Citations: 36

Year: 2016

Dual-layered 3D nanofibrous matrix incorporated with dual drugs and their synergetic effect on accelerating wound healing through growth factor regulation

Authors: S Singaravelu, G Ramanathan, UT Sivagnanam

Citations: 28

Year: 2017

New reinforcement detailing for concrete jacketing of nonductile exterior beamā€“column joints

Authors: KR Bindhu, N Mohana, S Sivakumar

Citations: 28

Year: 2016

Fabrication of biomimetic porous novel sponge from gum kondagogu for wound dressing

Authors: HS Rathore, M Sarubala, G Ramanathan, S Singaravelu, MD Raja, …

Citations: 25

Year: 2016

Bioceramic nanofibres by electrospinning

Authors: R Balu, S Singaravelu, N Nagiah

Citations: 25

Year: 2014

 

Pradeep Tyagi | Health Professions Award | Best Researcher Award

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Prof. Pradeep Tyagi | Health Professions Award | Best Researcher Award

Professor at University of Pittsburgh, United States

Pradeep Tyagi is a prolific researcher and educator with a strong focus on urology, bladder cancer, and drug delivery systems. His research contributions have significantly advanced the understanding and treatment of various urological conditions, including interstitial cystitis/bladder pain syndrome (IC/BPS) and urinary tract dysfunction. One of Pradeep’s key research interests lies in the development of targeted drug delivery systems, particularly ligand-targeted liposomes, for cancer treatment. His work in this area has shown promise in enhancing the efficacy of chemotherapy while minimizing side effects. Pradeep has also made significant contributions to the understanding of bladder cancer staging and treatment through the development of anisamide-targeted stealth liposomes for targeted drug delivery. In addition to his work in drug delivery systems, Pradeep has conducted research on the molecular mechanisms underlying lower urinary tract dysfunction, including the role of nitric oxide- soluble guanylate cyclase pathway in male bladder outlet obstruction. He has also investigated novel therapeutic targets for radiation cystitis and the use of urinary cytokines as noninvasive predictors of ulcerative interstitial cystitis.

Professional Profiles:

šŸ“š Education:

Pradeep Tyagi pursued his undergraduate education at Ch. Charan Singh University in India from November 1992 to September 1996, where he earned a Bachelor of Pharmacy degree in 1996. He continued his academic journey at the All India Institute of Medical Sciences, India, from August 1997 to May 1999, completing a Master of Science degree in Pharmacology. Pradeep then pursued his Ph.D. in Pharmaceutical Sciences at the School of Pharmacy, University of Pittsburgh, from August 2000 to April 2005, under the mentorship of Leaf Huang, PhD. His doctoral research focused on [specific topic or area of research]. To further enhance his skills and knowledge, Pradeep attended Katz Business School, University of Pittsburgh, from May 2021 to December 2022, where he completed an Executive MBA with a concentration in healthcare. This program provided him with a comprehensive understanding of business principles and strategies, particularly in the context of the healthcare industry, preparing him for leadership roles in the field.

Academic Experience:

Pradeep Tyagi’s academic career spans several prestigious institutions and roles. He served as a Visiting Research Scholar at the National University of Singapore in August 2001. From June 2001 to April 2005, he held the position of Teaching Fellow at the School of Pharmacy, University of Pittsburgh, where he contributed to the education of future pharmacists and pharmaceutical scientists. Moving forward, Pradeep became a Visiting Assistant Professor in the Department of Urology at the University of Pittsburgh from September 2006 to November 2008. He then took on the role of Director of Urology Lab at the Beaumont Research Institute in Royal Oak, MI, from November 2008 to November 2011, concurrently serving as an Associate Professor at the William Beaumont School of Medicine, Oakland University, Rochester, MI, from December 2010 to November 2011. Pradeep continued his academic endeavors as a Faculty Member at the OU-William Beaumont Institute for Stem Cell and Regenerative Medicine from March 2011 to 2015. He returned to the University of Pittsburgh in December 2011, where he held the position of Visiting Research Associate Professor in the Department of Urology until December 2020.

Awards and Honors:

Pradeep Tyagi’s exceptional contributions and achievements in academia and research have been recognized through numerous prestigious awards. In 2002, he received the ASPET Graduate Student Travel Award for the XIV World Congress of Pharmacology, highlighting his early excellence in the field. The following year, Pradeep was honored with the Graduate Student Research Excellence Award from the School of Pharmacy, University of Pittsburgh, for his outstanding research contributions. In 2004, Pradeep was awarded a Scholarship Award for a certificate course on developing entrepreneurship by the Office of Enterprise Development, University of Pittsburgh, showcasing his diverse skill set and interests. His commitment to urological research was further acknowledged in 2006 when he won the Annual Poster Contest organized by the Center of Urology Research Excellence at the University of Pittsburgh, focusing on hope and awareness for interstitial cystitis. Pradeep’s research prowess continued to garner recognition, with notable achievements such as winning the Best Basic Science Poster at the NIH, NIDDK Meeting on Urinary Incontinence in 2009, and receiving the Best Clinical Essay Prize on Biomarkers at the Winter Meeting of the Society of Urodynamics and Female Urology in the same year. His scholarly impact was also acknowledged through his selection for the Marquis Who’s Who in Medicine and Healthcare in 2009. In 2010, Pradeep achieved the Grand Prize in the International Jack Lapides Essay Contest on Urodynamic and Neuro-urology Research, further solidifying his position as a leading figure in the field. His contributions to academia were highlighted through awards such as the Best Paper Presented at the OU-Beaumont Symposium in 2011 and being a co-author of the Best Paper Presented at the OU-Beaumont Symposium in 2012. Pradeep’s commitment to excellence in research and scholarship was further demonstrated through his co-authorship of the Best AUA Poster on Prostatic Inflammation in 2012 and being the senior author of four posters judged best in sessions on benign prostatic hyperplasia (BPH), incontinence, and inflammation at the AUA in 2015. These awards and recognitions underscore Pradeep’s dedication to advancing the field of urology through his innovative research and scholarly contributions.

Research Focuse:

Pradeep Tyagi is actively involved in several research projects, contributing significantly to the advancement of urology and bladder cancer care. As a Principal Investigator, he leads the project “Advancing Bladder Cancer Care by Imaging and Intravesical Immune Checkpoint Blockade,” funded by grant R21 CA263243 from April 1, 2022, to March 31, 2024, with a total funding amount of $150,000. This project aims to enhance bladder cancer care through advanced imaging techniques and intravesical immune checkpoint blockade. Additionally, Pradeep serves as the Principal Investigator for grant R21CA252590, titled “Virtual Histology of the Bladder Wall for Bladder Cancer Staging,” receiving funding from August 1, 2020, to July 31, 2024, with a total award of $150,000. In this project, he focuses on developing virtual histology techniques to improve bladder cancer staging. Pradeep’s involvement extends to grant R44DK108397 (SBIR), where he leads the project “Phenotyping Interstitial Cystitis/Bladder Pain Syndrome by ICE-MRI Based Bladder Permeability Assay” as the Principal Investigator. This project, funded from September 15, 2022, to August 31, 2024, with a total award of $350,000, aims to characterize interstitial cystitis and bladder pain syndrome using advanced imaging techniques.

Teaching Experience:

Pradeep Tyagi has a rich teaching background, contributing significantly to the education and training of researchers and post-doctoral fellows. He has been actively involved in teaching seminars and lab meetings, imparting knowledge and expertise to aspiring researchers. From the year 2000 to 2003, Pradeep served as a Teaching Fellow at the School of Pharmacy, University of Pittsburgh, where he played a key role in educating students in pharmaceutical sciences. His dedication to teaching led him to team-teach the course PHARM 5219, Drug Development III, during the spring term of 2003. In this role, he served as a co-instructor, dedicating 8 contact hours per week to provide pre-lab instruction, supervise students, and evaluate their performance in the lab. He was also responsible for composing and administering exams for this course, ensuring comprehensive assessment of student learning. Furthermore, Pradeep took on the responsibility of administering and evaluating exams for the Biochemistry course 5117 and the Gastroenterology/Nutrition course 5317 in the years 2001 and 2002. His commitment to student learning and academic excellence has been evident throughout his teaching career, making him a valuable asset to the academic community.

Publications :

Ligand-targeted liposomes for cancer treatment

Authors: P Sapra, P Tyagi, TM Allen

Citations: 333

Year: 2005

Anisamideā€targeted stealth liposomes: a potent carrier for targeting doxorubicin to human prostate cancer cells

Authors: R Banerjee, P Tyagi, S Li, L Huang

Citations: 318

Year: 2004

Controlled gene delivery system based on thermosensitive biodegradable hydrogel

Authors: Z Li, W Ning, J Wang, A Choi, PY Lee, P Tyagi, L Huang

Citations: 217

Year: 2003

Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study

Authors: P Tyagi, D Barclay, R Zamora, N Yoshimura, K Peters, Y Vodovotz

Citations: 190

Year: 2010

Therapeutic receptor targets for lower urinary tract dysfunction

Authors: N Yoshimura, Y Kaiho, M Miyazato, T Yunoki, C Tai, MB Chancellor

Citations: 176

Year: 2008

Recent advances in intravesical drug/gene delivery

Authors: P Tyagi, PC Wu, M Chancellor, N Yoshimura, L Huang

Citations: 147

Year: 2006

Urinary nerve growth factor level is increased in patients with interstitial cystitis/bladder pain syndrome and decreased in responders to treatment

Authors: HT Liu, P Tyagi, MB Chancellor, HC Kuo

Citations: 146

Year: 2009

Urodynamic and immunohistochemical evaluation of intravesical botulinum toxin A delivery using liposomes

Authors: YC Chuang, P Tyagi, CC Huang, N Yoshimura, M Wu, J Kaufman

Citations: 144

Year: 2009

Qualitative and quantitative expression profile of muscarinic receptors in human urothelium and detrusor

Authors: S Tyagi, P Tyagi, S Van-le, N Yoshimura, MB Chancellor, F de Miguel

Citations: 131

Year: 2006

Sustained intravesical drug delivery using thermosensitive hydrogel

Authors: P Tyagi, Z Li, M Chancellor, WC De Groat, N Yoshimura, L Huang

Citations: 126

Year: 2004

Urinary nerve growth factor but not prostaglandin E2 increases in patients with interstitial cystitis/bladder pain syndrome and detrusor overactivity

Authors: HT Liu, P Tyagi, MB Chancellor, HC Kuo

Citations: 122

Year: 2010

Bladder afferent hyperexcitability in bladder pain syndrome/interstitial cystitis

Authors: N Yoshimura, T Oguchi, H Yokoyama, Y Funahashi, S Yoshikawa

Citations: 107

Year: 2014